All measurements were made at Vh=−70 mV and ECl=−21 mV. The recording electrode contained, among other constiuents, 100 mm potassium gluconate and 50 mM KCl. n, number of neurons; p value, significance level; P, probability of release. For other abbreviations see list on Introduction page.
Article: Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Dvorzhak A; Semtner M; Faber DS; Grantyn R J. Physiol. (Lond.), 2013
Property | WT | CAR | p value | Test | ||||
---|---|---|---|---|---|---|---|---|
Mean | ±SEM | n | Mean | ±SEM | n | |||
Basic characteristics (all connections) | ||||||||
Mean eIPSC amplitude (pA) | 170.74 | 10.81 | 108 | 116.29 | 6.80 | 101 | <0.0001 | Mann-Whitney’s U test |
Maximal eIPSC amplitude (pA) | 293.17 | 16.68 | 99 | 201.07 | 9.60 | 93 | <0.0001 | Mann-Whitney’s U test |
P (mean eIPSC/maximal eIPSC) | 0.58 | 0.01 | 99 | 0.53 | 0.01 | 93 | 0.0076 | Student's unpaired t test |
eIPSC failure rate (%) | 3.13 | 0.46 | 108 | 6.95 | 0.97 | 101 | 0.0228 | Mann-Whitney’s U test |
eIPSC CV (coefficient of variation, %) | 35.66 | 1.18 | 107 | 41.54 | 1.78 | 101 | 0.0059 | Student's unpaired t test |
Asyncronicity index (100 Hz test) | 0.96 | 0.16 | 18 | 2.41 | 0.35 | 16 | 0.0004 | Student's unpaired t test |
dIPSC integral (pA s) | 4.64 | 0.65 | 18 | 9.64 | 2.02 | 16 | 0.0192 | Student's unpaired t test |
PPR (eEPSC2/eEPSC1) | 0.71 | 0.01 | 108 | 0.81 | 0.02 | 101 | <0.0001 | Student's unpaired t test |
PPR % change by CB1 block | None | — | 14 | −7.50 | 3.00 | 9 | 0.0432 | Student's paired t test |
PPR % change by GABAB receptor block | −7.55 | 2.19 | 14 | None | — | 14 | 0.0195 | Student's paired t test |
Quantal analysis (based on 100 Hz test) | ||||||||
Q (median of dIPSC distribution; pA) | 29.46 | 3.03 | 18 | 35.08 | 1.69 | 16 | 0.1273 | Student's unpaired t test |
N (RRP = cumulative eIPSC at time 0/Q) | 19.39 | 2.69 | 18 | 14.79 | 2.32 | 16 | 0.2113 | Student's unpaired t test |
Pves (mean eIPSC/Q) | 0.41 | 0.03 | 18 | 0.32 | 0.02 | 16 | 0.0252 | Student's unpaired t test |
m (mean eIPSC/Q) | 7.04 | 0.65 | 18 | 4.41 | 0.61 | 16 | 0.0062 | Student's unpaired t test |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|